A SIGNALING PATHWAY MAP OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1/SERPINE-1): A REVIEW OF AN INNOVATIVE FRONTIER IN MOLECULAR AGING AND CELLULAR SENESCENCE

Abstract Plasminogen activator inhibitor-1 (PAI-1) is a vital regulator of the fibrinolytic mechanism and has been intricately involved in various physiological and clinical processes, including cancer, thrombosis, and wound healing.The PAI-1 signaling pathway is multifaceted, encompassing numerous signaling molecules and nodes.Recent studies have

The current property exchange methodology includes a lot of susceptibilities beetroot birkenstock and people use it to delude the common people and the government.Using blockchain, this project utilises majority consensus to implement secure asset transactions.The main objective behind the implementation of asset transaction using blockchain is to

Typically, smart city projects involve complex distributed systems having multiple stakeholders and diverse applications.These applications involve a multitude of sensor and IoT platforms for managing different types of timeseries observations.In many scenarios, timeseries data is the result of specific simulations and is stored in databases and ev

PurposeOral fluoropyrimidine (S-1, capecitabine) has been considered as an important part of various regimens.We aimed to evaluate the efficacy and safety of S-1-based therapy versus capecitabine -based therapy in gastrointestinal cancers.MethodsEligible studies were identified from Pubmed, EMBASE.Additionally, abstracts presented at American Socie